US HUPO 2023: Enabling Technology for Biological Discovery
March 4 – 8, 2023
At this year's US HUPO, MSAID will showcase CHIMERYS, an advanced search algorithm and AI-driven applications for proteomics.
POSTER PRESENTATIONS AT US HUPO
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P8.04 – A unifying, spectrum-centric approach for the analysis of peptide tandem mass spectra
Mass spectrometry-based proteomics data is acquired using data dependent (DDA), data independent (DIA) or targeted acquisition (PRM) methods. Typically, the former is analyzed using spectrum-centric algorithms assuming that it generates non-chimeric spectra, while the latter two are analyzed in a peptide-centric fashion. However, peptide-centric approaches often struggle to control for the contribution of multiple peptides to the experimental fragment ion intensity. Recently, we showed that DDA, and by extension PRM, spectra can be substantially chimeric and introduced an approach that deconvolutes spectra irrespective of isolation window size, thereby substantially boosting the number of identified peptides for DDA. Here, we demonstrate that the same approach generalizes to any chimeric MS2 spectrum, unifying the analysis of DDA, DIA and PRM data.
Date: Tuesday, March 7th
Location: The Drake Hotel in Chicago
Session: Poster Session 2 – 10:00 AM - 11:30 AM
PANEL DISCUSSION AT US HUPO
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LFQ Proteomics Battle Royale
Join us and other proteomics experts as we dive into the exciting world of label-free quantification using DDA, wide-window DDA and DIA.
Date: Sunday, March 5th
Location: The Drake Hotel in Chicago
Time: 4:30 PM
UPCOMING EVENTS
PAST EVENTS
14th International Symposium on Mass Spectrometry in the Health and Life Sciences (ASBMB)
August 14 – 18, 2022
Cambridge, MA, USA.
30th Conference on Intelligent Systems for Molecular Biology
(ISMB)
July 10 – 12, 2022
Madison, WI, USA.