INFERYS
VERSATILE DEEP LEARNING PLATFORM
DEEP LEARNING AT YOUR FINGERTIPS
INFERYS® is a versatile deep learning framework that provides highly accurate peptide property predictions. INFERYS‘ fragment ion intensity prediction is integrated into Thermo Scientific™ Proteome Discoverer™ software and enables INFERYS Rescoring and spectral library prediction at your fingertips. The all-new INFERYS 2.0 adds support for resonance-type (CID) fragmentation and Tandem Mass Tag™ derivatized peptides and improves predictions for non-tryptic peptides.
Top panels: density plots demonstrating the accuracy of fragment ion intensity predictions achieved by INFERYS 1.0 and 2.0 for resonance-type (CID) and beam-type (HCD) collision-induced dissociation data, as well as label-free and Tandem Mass Tag data. Distributions indicate the normalized spectral contrast angle of the holdout dataset. Bottom panels: INFERYS Rescoring performance on a typical desktop CPU.
DEEP LEARNING AT YOUR FINGERTIPS
+ INFERYS is aware of collision energies used for fragmentation and calibrates itself to provide predictions that best match your measured spectra.
+ To compensate for varying liquid chromatography setups, INFERYS utilizes a refinement learning strategy, improving on traditional statistical approaches.
+ The novel, intelligent search algorithm CHIMERYS is fueled by accurate predictions provided by INFERYS and enables a deeper, more comprehensive data analysis.
Top: collision energy (CE) calibration curves (normalized spectral contrast angle of prediction vs. experiment) for beam-type (HCD) fragmentation demonstrate the awareness and adaption of INFERYS. Each color corresponds to a different experimental CE, increasing from blue to red. Bottom: refinement learning enables alignment of retention times to any raw file with higher precision than classical statistical approaches.
INFERYS and CHIMERYS are integrated into Thermo Scientific™ Proteome Discoverer™ 3.0 software. For more information and licensing, please visit thermofisher.com/proteomediscoverer.
Thermo Scientific™ Proteome Discoverer™, Thermo Scientific™ Orbitrap™ are trademarks of Thermo Fisher Scientific, Inc. Tandem Mass Tag, TMT™, and TMTpro™ are trademarks of Proteome Sciences plc.
If you would like to learn what a customized deep learning model can do for your research, feel free to contact us!